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Scientific papers currently pre-publication

(links to abstracts of papers in pre-publication stage, or not yet free to public view)

New!
European Journal of Vascular and Endovascular Therapy, published online, 12 August 2011
Zamboni P, Galeotti R, Weinstock-Guttman B, Kennedy C, Salvi F, Zivadinov R

View abstract as HTML: Venous Angioplasty in Patients with Multiple Sclerosis: Results of a Pilot Study

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New!
Journal of Endovascular Therapy, Volume 18, Issue 3 (June 2011)
Petrov I, Grozdinski L, Kaninski G, Iliev N, Iloska M, and Radev

View abstract as HTML: Safety Profile of Endovascular Treatment for Chronic Cerebrospinal Venous Insufficiency in Patients With Multiple Sclerosis

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J Neurol Neurosurg Psychiatry. 2010 Oct
Wattjes MP, van Oosten BW, de Graaf WL, Seewann A, Bot JC, van den Berg R, Uitdehaag BM, Polman CH, and Barkhof F
van Rensburg SJ, and van Toorn R

Paper critical of theory of link between CCSVI and MS

View abstract as HTML: No association of abnormal cranial venous drainage with multiple sclerosis: a magnetic resonance venography and flow-quantification study

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Neurology. 2010 Sep
van Rensburg SJ, and van Toorn R

View abstract as HTML: The controversy of CCSVI and iron in multiple sclerosis: Is ferritin the key?

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Pathophysiology. 2010 Jul
J. Steven Alexander, Robert Zivadinov, Amir-Hadi Maghzi, Vijay C. Ganta, Meghan K. Harris and Alireza Minagar

View abstract as HTML:
 Multiple sclerosis and cerebral endothelial dysfunction: Mechanisms

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J Neurosci Res 2010 Feb.
Simka M, and Zaniewski M

View abstract as HTML: Reinterpreting the magnetic resonance signs of hemodynamic impairment in the brains of multiple sclerosis patients from the perspective of a recent discovery of outflow block in the extracranial veins
View in PubMed:

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J Neurol Sci 2010 Jan
Qiu W, Raven S, Wu JS, Carroll WM, Mastaglia FL, and Kermode AG

View abstract as HTML:     Wedge-shaped medullary lesions in multiple sclerosis

View in PubMed:

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Neurology 2009 Sep;73(13):1006-7
Pirko I, and Zivadinov R

View abstract in PubMed:     Transcranial sonography of deep gray nuclei: a new outcome measure in multiple sclerosis?

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Int Angiol 2009 Dec;28(6):434-51. Montecarlo September 4th 2009
Lee BB, Bergan J, Gloviczki P, Laredo J, Loose DA, Mattassi R, Parsi K, Villavicencio JL, and Zamboni P

View abstract as HTML: Diagnosis and treatment of venous malformations Consensus Document of the International Union of Phlebology (IUP)-2009
View in PubMed:

A Consensus Conference on Venous Malformations – headed by Prof. Byung B Lee from Georgetown – and experts from 47 countries – studied the evidence and voted unanimously in favour of officially including the stenosing lesions found in CCSVI in the new Consensus document and Guidelines.
CCSVI is now classified among venous malformations.


back to index of studies in progress

USA

  

Study:

Study To Evaluate Treating Chronic Cerebrospinal Venous Insufficiency (CCSVI) in Multiple Sclerosis Patients
500 Person (interventional study)

Utility of Chronic Cerebrospinal Venous Insufficiency Percutaneous Angioplasty for Multiple Sclerosis: The Albany Vascular Group Study (Liberation Study)

Current Status:

 Currently recruiting participants.  United States: Institutional Review Board (IRB) approved

Centre:

 The Vascular Group, PLLC, The Vascular Pavillion, Albany, New York, United States, 12205 Albany NY, USA

Conducted by:
Dr. Manish Mehta, MD, MPH   (primary investigator),
Description:
Study to evaluate treating chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis patients.

Primary Outcome Measures:

* Incidence of major adverse events [ Time Frame: 30 days ] [ Designated as safety issue: Yes ]
The evaluation of safety will be defined as the incidence of major adverse events at 30 days following the index procedure. The evaluation of feasibility and efficacy will be determined by those patients that do not have more than 50 percent restenosis within the 30 day time frame.

Secondary Outcome Measures:

* Mortality [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]
Secondary endpoints will be evaluated with all subjects based upon mortality, incidence of all secondary interventions and incidence of all major adverse events for a period of 2 years.

Estimated Enrollment: 500
Study Start Date: August 2010
Estimated Study Completion Date: September 2011
Estimated Primary Completion Date: September 2011 (Final data collection date for primary outcome measure)
Intervention Details:

* Procedure: Angioplasty
To identify the presence of CCSVI, all patients will undergo a clinical evaluation by a neurologist, a duplex ultrasound of central extracranial venous system, an MRV, and a venogram. The decision to enroll patient in percutaneous angioplasty for CCSVI will be made at the time of venogram, in select patients that have greater than or equal to 50 percent stenosis of the extracranial central veins including the internal jugular veins and the azygos vein. Extracranial venous ultrasound will be performed at 3, 6, 12, 18, and 24 months following the procedure or if clinical symptoms recur. MRV and venograms will be performed at 12months and 24 months or if clinical symptoms recur.

Reports:

View study as HTML:     Study To Evaluate Treating Chronic Cerebrospinal Venous Insufficiency (CCSVI) in Multiple Sclerosis Patients

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                                                                                     of the symptoms labelled Multiple Sclerosis.  Individuals should always seek medical advice from their doctor.